Malaria prevention is critical for multinational companies that operate in areas with a high risk of the disease because malaria not only adversely affects the health of workers but also leads to economic losses associated with mortality and morbidity. A global company with operations in areas with malaria-transmission risk has an established workplace malaria-control program that uses a multipronged approach of awareness, bite prevention, chemoprophylaxis, and early diagnosis and treatment to protect the health and safety of company workers.
Chemoprophylaxis is an emphasized component of the malaria-control program. Adherence to medications is the process by which patients take their medications as prescribed. Laboratory methods have been developed to test urine for the presence of malaria-preventive medicines. To gain efficiency and real-time results, a rapid detection test (RDT) for mefloquine, proguanil, and doxycycline was developed. This paper describes the development of the immunochromatographic test for quick detection of the malaria-preventive medicines. The test integration and observed results also are presented for potential adoption by organizations seeking to improve adherence to malaria prevention for workers in endemic locations.
The first tests successfully developed were for proguanil and mefloquine, followed two years later by doxycycline. The RDT validity was tested against the standard laboratory techniques, which use high-performance liquid chromatography. The paper describes the validation process adopted for the doxycycline test because it closely mirrors what was done with mefloquine and proguanil.
Find the paper on the HSE Technical Discipline Page free for a limited time.
Don't miss our latest HSE content, delivered to your inbox twice monthly. Sign up for the HSE Now newsletter. If you are not logged in, you will receive a confirmation email that you will need to click on to confirm you want to receive the newsletter.
11 Nov 2018
- Abu Dhabi, UAE
Training course by Dr. Kamel Ben-Naceur
5 - 6 Nov 2018
- The Hague, The Netherlands
Online Registration is Open!
12 - 15 Nov 2018
- Abu Dhabi, UAE
Join us for this key regional event.
29 - 31 Oct 2019
- Bali, Indonesia
Call for Papers is Now Open.
8 - 9 Oct 2018
- Kuala Lumpur, Malaysia
Well integrity is often managed as part of the asset’s lifecycle production and maintenance. But ageing wells pose new challenges. Learn how to manage integrity sustainably.
HSE Now is a source for news and technical information affecting the health, safety, security, environment, and social responsibility discipline of the upstream oil and gas industry.
©2003-2018 Society of Petroleum Engineers, All Rights Reserved.